abstract：:The reversibility and time course of the adaptive changes in hepatic bile salt transport related to modifications of the bile salt enterohepatic circulation and bile salt pool size have not been previously studied. For this reason a model of reversible interruption of entero-hepatic circulation was characterized in un...

journal_title：Journal of hepatology

authors： Accatino L,Hono J,Koenig C,Pizarro M,Rodriguez L

更新日期：1993-08-01 00:00:00

abstract：:The aim of the present study was to identify the cell types that express collagen alpha 1(I), alpha 1(III) and alpha 1(IV), fibronectin and laminin B1 genes in normal rat liver. Parenchymal, sinusoidal endothelial, Kupffer and fat-storing (Ito) cells were isolated and purified. Total RNA of the freshly isolated cells ...

journal_title：Journal of hepatology

authors： Geerts A,Greenwel P,Cunningham M,De Bleser P,Rogiers V,Wisse E,Rojkind M

更新日期：1993-08-01 00:00:00

abstract：:HCV is the principal etiologic agent of post-transfusion (PTH) hepatitis. The incidence and course of HCV hepatitis in liver transplant recipients is not well established. To resolve this information deficit, all records of recipients of single liver transplant (OLTx) between March 1986 and March 1990 at the Universit...

journal_title：Journal of hepatology

authors： Shah G,Demetris AJ,Irish W,Scheffel J,Mimms L,Van Thiel DH

更新日期：1993-07-01 00:00:00

abstract：:Recently antibodies to hepatitis C virus were detected in sera of chronic active hepatitis patients, with anti-smooth muscle autoantibodies or with anti-liver/kidney microsomal type 1 autoantibodies. As the latter were used to differentiate autoimmune chronic active hepatitis from chronic non-A, non-B virus hepatitis,...

journal_title：Journal of hepatology

authors： Abuaf N,Lunel F,Giral P,Borotto E,Laperche S,Poupon R,Opolon P,Huraux JM,Homberg JC

更新日期：1993-07-01 00:00:00

abstract：:An HBV strain isolated from a patient lacking conventional serological markers of HBV infection was characterized. The complete nucleotide sequence was determined following PCR amplification. Only 22 nucleotide substitutions were found relative to the reported sequence of the ayw subtype. Five of these point mutations...

journal_title：Journal of hepatology

authors： Kremsdorf D,Garreau F,Duclos H,Thiers V,Schellekens H,Petit MA,Bréchot C

更新日期：1993-06-01 00:00:00

abstract：:Treatment of hepatic fibrosis by simple and inexpensive therapies is a new challenge for the near future. Hepatic fibrosis which may lead to cirrhosis, is indeed associated with most chronic liver diseases and affects millions of people. During the last decade, major breakthroughs have been accomplished in the field o...

journal_title：Journal of hepatology

authors： Clément B,Loréal O,Levavasseur F,Guillouzo A

更新日期：1993-04-01 00:00:00

abstract：:Occasionally direct sequencing of amplified hepatitis B virus DNA leads to weak signals on autoradiograms. Using amplified C-gene sequences we investigated whether this is due to sequence heterogeneity of virus populations and use of inappropriate primers for direct sequencing. High C-gene sequence heterogeneity (poin...

journal_title：Journal of hepatology

authors： Miska S,Günther S,Vassilev M,Meisel H,Pape G,Will H

更新日期：1993-04-01 00:00:00

abstract：:We investigated whether regulation of interferon-alpha gene expression could be involved in liver tumor biology and the role, if any, of hepatitis B virus in the regulation of tumor cytokine gene expression. Gene expression was investigated at the transcriptional level using 'in situ' hybridization of cytokine message...

journal_title：Journal of hepatology

authors： d'Arville CN,Nouri-Aria KT,Johnson P,Williams R

更新日期：1993-03-01 00:00:00

abstract：:Thirty-two patients with chronic hepatitis B were randomly assigned to two groups. Sixteen patients received 10 million units of alpha-interferon per square meter of body surface (MU/m2), three times weekly for 4 months. Sixteen patients were treated simultaneously with gamma-interferon at a dose of 2 MU/m2, and 10 MU...

journal_title：Journal of hepatology

authors： Carreño V,Moreno A,Galiana F,Bartolomé FJ

更新日期：1993-03-01 00:00:00

abstract：:Secondary biliary cirrhosis in the rat is an attractive model since unlike other models it does not rely on exogenous toxic compounds to induce cirrhosis. However, because little is known about the microcirculatory abnormalities of this model, this study investigated hemodynamics in rats with predefined functional imp...

journal_title：Journal of hepatology

authors： Ohara N,Schaffner T,Reichen J

更新日期：1993-02-01 00:00:00

abstract：:The prevalence of antibodies to hepatitis C virus (anti-HCV) in a hepatitis B virus hyperendemic region was evaluated with a second-generation enzyme immunoassay. A general population of 1500 from Northern Taiwan was tested with this immunoassay which includes synthetic peptides from the capsid and non-structural prot...

journal_title：Journal of hepatology

authors： Sheu JC,Wang JT,Wang TH,Wang CY,Yang PM,Huang GT,Shih LN,Lee HS,Chen DS

更新日期：1993-02-01 00:00:00

abstract：:Medical treatment of cirrhotic ascites is essentially supportive, dictated by the patient's discomfort, impaired cardiovascular or respiratory function and potential for infection. Treatment of 'simple' ascites (moderate fluid accumulation, serum albumin > 3.5 g/dl, serum creatinine < 1.5 mg/dl, no electrolyte disturb...

journal_title：Journal of hepatology

authors： Gerbes AL

更新日期：1993-01-01 00:00:00

abstract：:It has been postulated that one of the mechanisms of hypotension associated with cirrhosis is an attenuated responsiveness to catecholamines despite the increased activity of the sympathetic nervous system and the elevated plasma concentrations of the sympathetic neurotransmitter, norepinephrine. This abnormality was ...

journal_title：Journal of hepatology

authors： Bomzon A,Binah O,Blendis LM

更新日期：1993-01-01 00:00:00

abstract：:The prognostic value of portal hemodynamics, measured by pulsed echo-Doppler, was prospectively evaluated, together with clinical, biochemical and endoscopic parameters, in a series of 50 consecutive patients with compensated cirrhosis. After a mean follow-up of 6 years, 25 patients had died, all from complications of...

journal_title：Journal of hepatology

authors： Zoli M,Iervese T,Merkel C,Bianchi G,Magalotti D,Marchesini G,Gatta A,Pisi E

更新日期：1993-01-01 00:00:00

abstract：:A total of 37 patients with histologically confirmed chronic viral hepatitis B and presence of HBV-DNA and HBsAg in the serum were treated in a randomized, prospectively controlled multicenter trial either with recombinant IFN alpha-2b alone or a combination of IFN alpha-2b and recombinant IL-2. Twenty-two patients fr...

journal_title：Journal of hepatology

authors： Bruch HR,Korn A,Klein H,Markus R,Malmus K,Baumgarten R,Müller R

更新日期：1993-01-01 00:00:00

abstract：:Hepatitis A virus (HAV) infection in adults is often symptomatic and disabling. The present article summarizes our experience with phase 2 studies of an inactivated hepatitis A virus vaccine. Pre- and post-exposure prophylaxis with immune globulin (IG) is only effective for 4-6 months. We compared the safety, tolerabi...

journal_title：Journal of hepatology

authors： Shouval D,Ashur Y,Adler R,Lewis JA,Miller W,Kuter B,Brown L,Nalin DR

更新日期：1993-01-01 00:00:00

abstract：:The possible aggravation of liver injury by impaired cellular antioxidant function was investigated. A vitamin E-deficient diet (0.5 mg/kg alpha-tocopherol; control 100 mg/kg) significantly reduced rat liver alpha-tocopherol concentrations after 4 weeks (1.8 +/- 1.7 micrograms/g; control 34.4 +/- 2.4 micrograms/g, p <...

journal_title：Journal of hepatology

authors： Barrow L,Patel HR,Tanner MS

更新日期：1992-11-01 00:00:00

abstract：:This study reports that thrombocytopenia is a universal phenomenon post hepatic transplantation. In 53 consecutive adult patients undergoing liver transplantation the platelet count fell by a mean of 63% (157 x 10(9)/l to 50 x 10(9)/l). The platelet count reached a nadir at Day 5 post-transplant but returned to pre-op...

journal_title：Journal of hepatology

authors： McCaughan GW,Herkes R,Powers B,Rickard K,Gallagher ND,Thompson JF,Sheil AG

更新日期：1992-09-01 00:00:00

abstract：:All routinely available assays to detect hepatitis C virus (HCV) infection are based on the specific reaction of serum antibodies to corresponding viral antigens. The only method to detect viral nucleic acids in serum or liver is the enzymatic amplification of reversely transcribed HCV-RNA by polymerase chain reaction...

journal_title：Journal of hepatology

authors： Geiger CP,Caselmann WH

更新日期：1992-07-01 00:00:00

abstract：:The results of a 3-year, placebo-controlled trial of prednisolone treatment in primary biliary cirrhosis (PBC) are presented. The active (n = 19) and placebo (n = 17) arms were initially well matched for age, menopausal status and disease severity. At 3 years hepatic symptoms were relatively improved in the prednisolo...

journal_title：Journal of hepatology

authors： Mitchison HC,Palmer JM,Bassendine MF,Watson AJ,Record CO,James OF

更新日期：1992-07-01 00:00:00

abstract：:Thirty-five consecutive patients with primary biliary cirrhosis were examined using liver biopsy, laboratory tests and ultrasonography of the hepato-duodenal ligament to investigate the possible correlation between enlarged lymph nodes in the hepato-duodenal ligament and biochemical activity, histologic activity or st...

journal_title：Journal of hepatology

authors： Lyttkens K,Prytz H,Forsberg L,Hederström E,Hägerstrand I

更新日期：1992-05-01 00:00:00

abstract：:The epidemiology of HDV infection in Italy was assessed in a retrospective study involving 1556 HBsAg chronic carriers on their first presentation at one of the 35 Liver Units in 1987. Total anti-HD was detected in 23.4% of HBsAg carriers and was significantly more frequent in southern than in northern Italy (26.6% vs...

journal_title：Journal of hepatology

authors： Sagnelli E,Stroffolini T,Ascione A,Bonino F,Chiaramonte M,Colombo M,Craxi A,Giusti G,Manghisi OG,Pastore G

更新日期：1992-05-01 00:00:00

abstract：:We previously reported that high-dose ursodeoxycholate (UDC) infusion in rats resulted in extensive glucuronidation of UDC, and speculated that the glucuronidation causes bicarbonate-rich hypercholeresis induced by UDC (Takikawa, H., Sano, N., Narita, T. and Yamanaka, M. Hepatology 1990; 11: 743-749). To test this hyp...

journal_title：Journal of hepatology

authors： Takikawa H,Sano N,Minagawa K,Yamanaka M

更新日期：1992-05-01 00:00:00

abstract：:In an attempt to evaluate the prevalence, kinetics and impact of HCV infection in renal transplantation, we analyzed 140 kidney recipients according to the histopathological status of the liver. Thirty-three HBsAg-negative patients had chronic active hepatitis, 73 HBsAg-negative patients had a normal liver, 21 HBsAg-n...

journal_title：Journal of hepatology

authors： Pol S,Legendre C,Saltiel C,Carnot F,Bréchot C,Berthelot P,Mattlinger B,Kreis H

更新日期：1992-05-01 00:00:00

abstract：:The coagulation inhibitor protein C was measured in 151 patients with various liver diseases. The protein C level was significantly decreased in patients with alcoholic cirrhosis (n = 73) compared to patients with steatosis (n = 24) (40 +/- 2%) vs. 88 +/- 4%, mean S.E., p less than 0.001). It was also decreased in cas...

journal_title：Journal of hepatology

authors： Bell H,Odegaard OR,Andersson T,Raknerud N

更新日期：1992-03-01 00:00:00

abstract：:The purpose of the present study was to determine the effects of chronic portal diversion on antioxidant levels in the rat liver. Male Sprague-Dawley rats (n = 32) were used for these studies. An end-to-side portacaval anastomosis was constructed in 17 of the rats. Sham-operated rats (n = 15) served as controls. Two w...

journal_title：Journal of hepatology

authors： Benoit JN,Grisham MB,Mesh CL,Korthuis RJ,Granger DN

更新日期：1992-03-01 00:00:00

abstract：:The effect of amphotericin B on hepatic microsomal cytochrome P-450 (P-450) concentration was measured in vitro, in vivo and ex vivo in the rat. In vitro, both amphotericin B (0-500 micrograms/ml) and its vehicle, sodium deoxycholate (0-410 micrograms/ml), caused similar dose-dependent decreases of P-450 concentration...

journal_title：Journal of hepatology

authors： Heidemann H,Holzlöhner U,Heydemann J,Freitag T,Inselmann G

更新日期：1992-03-01 00:00:00

abstract：:The implications of hepatitis B virus (HBV) reinfection after liver transplantation were studied in 29 patients followed for 1.7-15 years. Of 20 patients with HBV infection alone, nine were HBeAg and HBV DNA seronegative and 11 had evidence of HBV replication as measured by HBeAg or HBV DNA seropositivity. Nine patien...

journal_title：Journal of hepatology

authors： O'Grady JG,Smith HM,Davies SE,Daniels HM,Donaldson PT,Tan KC,Portmann B,Alexander GJ,Williams R

更新日期：1992-01-01 00:00:00

abstract：:Twelve cirrhotic patients and six controls were fed an eucaloric high carbohydrate (CHO) diet for 3 days. Fasting serum triglyceride (TG), non-esterified fatty acids (NEFA), glucose, insulin and glycerol were estimated daily. On the 3rd day of the study we measured NEFA, glucose, insulin, and fructose every 45 min fro...

journal_title：Journal of hepatology

authors： Avgerinos A,Harry D,Bousboulas S,Theodossiadou E,Komesidou V,Pallikari A,Raptis S,McIntyre N

更新日期：1992-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) variants with a stop codon, a mutated translation initiation codon or other mutations in the pre-C region which prevent e-antigen expression are highly prevalent in anti-HBe chronic carriers and can be positively selected from a mixed virus infection. Our laboratories recently described pre-C v...

journal_title：Journal of hepatology

authors： Santantonio T,Jung MC,Schneider R,Pastore G,Pape GR,Will H

更新日期：1991-11-01 00:00:00

abstract：:The diagnostic performance of an Expert System (Jaundice) designed to discriminate between different causes of jaundice was evaluated in a test sample of 200 consecutive in-patients with serum bilirubin greater than or equal to 51 mumol/l. The average probability assigned to true diagnosis, the non-error rate and the ...

journal_title：Journal of hepatology

authors： Cammà C,Garofalo G,Almasio P,Tinè F,Craxì A,Palazzo U,Pinzello G,Fiorello F,Angelo PM,Pagliaro L

更新日期：1991-11-01 00:00:00

abstract：:One hundred and eight patients with cirrhosis (23 grade A, 46 grade B and 39 grade C, according to Pugh's classification) underwent hemodynamic studies and plasma catecholamine concentration measurements. Blood samples were withdrawn from the pulmonary artery (n = 108), the hepatic vein (n = 108), the azygos vein (n =...

journal_title：Journal of hepatology

authors： Gaudin C,Braillon A,Poo JL,Moreau R,Hadengue A,Lebrec D

更新日期：1991-09-01 00:00:00

abstract：:Intraperitoneal inoculation into sensitive BALB/c mice of D85, a thermosensitive (ts) mutant, provokes acute hepatitis followed by recovery of the mice. The ts mutant was able to replicate in the liver. However, the maximal viral titre was obtained 2 days later than was the case with the wild-type (wt) MHV 3 infection...

journal_title：Journal of hepatology

authors： Martin JP,Bingen A,Koehren F,Gut JP,Kirn A

更新日期：1991-07-01 00:00:00

abstract：:Twenty patients with paracetamol(acetaminophen)-induced acute liver damage of varying severity were studied longitudinally with assessment of clinical state, standard liver function tests and radiometric hyaluronate (HYA) assay (Pharmacia). In patients (n = 6) who developed coma, HYA rose rapidly with clinical deterio...

journal_title：Journal of hepatology

authors： Bramley PN,Rathbone BJ,Forbes MA,Cooper EH,Losowsky MS

更新日期：1991-07-01 00:00:00

abstract：:In order to evaluate age at menopause and serum sex hormone profiles in postmenopausal women with stable chronic liver disease, six non-cirrhotic alcoholics, 13 with alcoholic cirrhosis, eight with non-alcoholic cirrhosis, and 46 healthy controls were studied. In all three groups, patients were significantly (p less t...

journal_title：Journal of hepatology

authors： Becker U,Gluud C,Farholt S,Bennett P,Micic S,Svenstrup B,Hardt F

更新日期：1991-07-01 00:00:00

abstract：:We describe a new model of submaximal stimulation of liver regeneration in the rat. Removal of the right lateral lobes in the rat produced a 21% hepatectomy. The measurement accuracy of the incorporation rate of [14C]thymidine into DNA 24 h after 21% hepatectomy (n = 32) was less than that after the standard 34% hepat...

journal_title：Journal of hepatology

authors： Baruch Y,Frith LO,Kirsch RE

更新日期：1991-05-01 00:00:00

abstract：:To evaluate the expression of hepatocyte HLA Class I and II antigens and the infiltration of CD8-positive lymphocytes in patients with chronic hepatitis, cells obtained by the technique of fine-needle aspiration were compared with those obtained by percutaneous liver biopsy. In general, correlation between cytological...

journal_title：Journal of hepatology

authors： Krawitt EL,Zannier A,Chossegros P,Gerard F,Chevallier M,Mutin M,Trepo C,Touraine JL

更新日期：1991-03-01 00:00:00

abstract：:The aims of this study were to evaluate bone metabolism in primary biliary cirrhosis (PBC) and the effect of ADFR (activate, depress, free, repeat) therapy with vitamin D, calcium and calcitonin in preventing bone resorption. Sixty-nine female subjects entered the study: 38 PBC (AMA + ve) patients, 11 AMA-negative chr...

journal_title：Journal of hepatology

authors： Floreani A,Chiaramonte M,Giannini S,Malvasi L,Lodetti MG,Castrignano R,Giacomini A,D'Angelo A,Naccarato R

更新日期：1991-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) cDNA sequence in the nonstructural region NS3 was amplified from the serum of 66% French non-A, non-B hepatitis patients by the nested polymerase chain reaction. A 407 base-pair sequence was determined from four such cases, which revealed the presence of two different virus genotypes F1 (three ...

journal_title：Journal of hepatology

authors： Li JS,Tong SP,Vitvitski L,Lepot D,Trépo C

更新日期：1991-01-01 00:00:00

abstract：:Mutant HBV genomes unable to produce preS2 protein were identified in the serum of a highly viremic chronic carrier. By direct sequencing of the amplified preS region and by sequencing of 50 cloned amplified preS DNA fragments all molecules were found to have deleted the preS2 translation initiation codon and three am...

journal_title：Journal of hepatology

authors： Fernholz D,Stemler M,Brunetto M,Bonino F,Will H

更新日期：1991-01-01 00:00:00